A virtual, culturally grounded intervention helped urban American Indian and Alaska Native emerging adults reduce several measures of substance use and anxiety, according to a randomized clinical trial published in JAMA Network Open. In this study, both groups received culturally grounded virtual support focused on reducing alcohol and other drug use. Subject of Research: Virtual culturally grounded interventions for alcohol and other drug use among urban American Indian and Alaska Native emerging adults. Randomized clinical trial of two virtual culturally grounded interventions for substance use among urban American Indian and Alaska Native emerging adults. Keywords: American Indian and Alaska Native health, emerging adults, virtual intervention, culturally grounded care, substance use, alcohol use, cannabis use, heroin exposure, anxiety, urban populations, tribal communities, randomized clinical trial.