A risk score based on CA125, CEA, and AFP levels was developed using LASSO-Cox regression, and nomograms were constructed for survival prediction. The risk score incorporating CA125, AFP, and CEA was an independent indicator for both PFS (P<0.0001) and OS (P<0.0001). Nomograms based on the risk score and clinicopathological features demonstrated good predictive ability and calibration for survival outcomes. Conclusions: The risk score based on preoperative serum levels of CA125, CEA, and AFP is a valuable prognostic tool for predicting PFS and OS in EC patients. Nomograms incorporating this risk score accurately predict EC prognosis and may aid in clinical decision-making.