In Huntington's disease, an inherited condition caused by a faulty gene, these structures are gradually damaged, leading to worsening problems with movement, thinking and mood. In Huntington's disease, neurons in a part of the basal ganglia called the striatum gradually die. tested a new diffusion MRI model called SANDI (Soma and Neurite Density Imaging), which estimates the apparent density and size of cell bodies. The researchers analysed brain scans from 56 people with Huntington's disease and 57 healthy volunteers. In the future, SANDI could help doctors and researchers track how Huntington's disease progresses and determine whether new treatments are protecting brain cells.