Cancer cells grow at breakneck speed-but that relentless pace may come at a cost. Researchers from the Hebrew University of Jerusalem found that powerful DNA control regions called super-enhancers push cancer-related genes into overdrive. Cancer cells repeatedly repaired this damage, allowing them to survive—but each repair carried the risk of introducing new mutations. Lead researcher Osama Hidmi added that these stressed DNA regions could become an Achilles’ heel for cancer cells. Superenhancers shape the landscape and repair dynamics of transcription-associated DNA breaks in cancer.