A new study published in the Journal of the American Medical Association showed that in cryptogenic stroke, anticoagulation may be more effective than antiplatelet therapy in patients without high-risk hypertension features, while hypertension-related vascular disease may alter treatment response. Cryptogenic stroke is a heterogeneous condition with varied underlying mechanisms. Hypertension risk stratification may help identify patients with cryptogenic stroke who are more likely to benefit from anticoagulation therapy. Overall, 37% of participants met the criteria for high-risk hypertension, and across the study population, 67 recurrent events were recorded over a median follow-up of 1.6 years. Hypertension With High-Risk Features in Cryptogenic Stroke: An Exploratory Analysis of the ARCADIA Randomized Clinical Trial.