NHS safety warning over paracetamol and ibuprofen drug interactionsThe NHS has issued a warning for those taking certain medications to be cautious when using painkillers such as paracetamol and ibuprofen. The health service has recommended consulting your GP before taking paracetamol or ibuprofen if you're affected. If this situation applies to you, you should seek advice from your doctor before taking paracetamol, the health authority states. The NHS advises consulting your GP before using paracetamol if you're taking medication for epilepsy or tuberculosis (TB) as this may also pose risks. The health service has warned people against taking ibuprofen at the same time as other nonsteroidal anti-inflammatory drugs (NSAIDs).