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STAT+: Silence Therapeutics aims at Takeda with new data in rare blood cancer
['Jason Mast', 'Jason Is A General Assignment Reporter', 'With Particular Focus On Genetic Medicine', 'Rare Disease. Confidential Tips Can Be Sent On Signal At', 'General Assignment Reporter', 'O. Rose Broderick', 'Angus Chen', 'Adam Feuerstein', 'Allison Deangelis', 'Meghana Keshavan']
STAT
Jason is a general assignment reporter, with particular focus on genetic medicine and rare disease.
An experimental medicine from Silence Therapeutics stabilized red blood cell levels in patients with a rare blood cancer in a new trial — a result that could position it to compete with a drug from Takeda Pharmaceuticals that is nearing approval.
The cancer, polycythemia vera, is marked by runaway production of red blood cells and puts patients at risk of life-threatening blood clots, bleeds, and other cancers.
AdvertisementIn the 48-person, Phase 2 trial, 88% of patients who received Silence’s drug, called divesiran, every six weeks or 12 weeks achieved a clinical response, the company said Monday.
By contrast, only 19% of patients on placebo did.