As crackdowns have pushed the drug supply to evolve more quickly and chaotically, fentanyl has gradually begun showing up with non-opioid drugs. The public is now moderately more aware that there is no such thing as secondhand fentanyl overdose. There is no evidence to suggest that secondhand exposure to synthetic opioids or cannabinoids poses any kind of risk. Meth Overdose CrisisOpioid overdose is potentially fatal because opioid molecules can bind to the brainstem receptors that regulate breathing; the mechanism of death is respiratory depression. Because that is the bias of the system,” a toxicologist who signs off on drug death reports told Filter in 2023.