That’s exactly what an international team has achieved: nearly 700 new patient-derived cancer models, representing 25 different cancer types, are now available to researchers worldwide. Published in Nature, this milestone is the result of a 10-year initiative led by MIT’s Koch Institute, the Broad Institute, Dana-Farber Cancer Institute, the National Cancer Institute, and many other partners. These patient-derived models are providing powerful new weapons for cancer researchers to explore. Ever since the Cancer Genome Atlas and its launch of The Human Cancer Models Initiative in 2016, this has been a crusade to broaden an ever-shrinking pool of patient‑derived cancer cell lines. All these models generated through the Human Cancer Models Initiative (HCMI) have been stored at the American Type Culture Collection (ATCC), together with a wealth of patient data including inherited mutations and treatment history.