Diabetic foot ulcers are a serious complication of diabetes associated with amputation, mortality, and substantial healthcare burden. Single cell analysis of 13 diabetic foot ulcer samples further indicated that GRHL2 was predominantly expressed in keratinocytes. Based on these results, the researchers established a model of mesenchymal fibroblast to supraspinous keratinocyte transition during diabetic foot ulcer repair. Immunofluorescence analysis of clinical diabetic foot ulcer samples was subsequently used to validate GRHL2 expression. Molecular docking additionally identified parthenolide, MG 132, mitoxantrone, and irinotecan as compounds with potential activity relevant to diabetic foot ulcers.