Fish buttholes and fingers may seem like an unlikely pair, but new research suggests a surprising connection between the two. A groundbreaking study reveals that the DNA switch that governs the development of human digits likely originated from a fish’s cloaca—an all-purpose orifice used for excretion and reproduction. This revelation connects our hands with something as unexpected as fish buttholes, providing a remarkable evolutionary twist. From Fish Cloacas to Human Fingers: A 380 Million-Year-Old DNA StoryScientists have long been trying to unravel how tetrapods—four-limbed creatures like us—developed fingers from their fish ancestors. Credit: CanvaThe connection between fish buttholes and human fingers is more than just a quirky fact—it’s a profound testament to the ingenuity of evolutionary processes.