The U.S. Environmental Protection Agency (EPA) has extended its Emerging Viral Pathogen (EVP) Guidance for Antimicrobial Pesticides (Guidance) in response to the mpox virus (formerly monkeypox), which had been considered to be a rare disease caused by infection with the mpox virus. EPA developed its Guidance in 2016 to address emerging pathogens. EPA provides the searchable List Q: Disinfectants for Emerging Viral Pathogens (EVPs). Mpox virus is a Tier I (enveloped virus); thus, when disinfectants damage their lipid envelope, the virus is no longer infectious. EPA initially activated the EVP Policy for the mpox virus in August 2024.