One of the greatest challenges in modern genetics is schizophrenia. Understanding this complex genetic architecture requires more than just identifying a single root cause of the problem. The team identified 766 genes associated with schizophrenia, including 641 that had not appeared in previous transcriptomic analyses. Rather than acting separately, the variants appear to coordinate and collectively contribute to the risk of developing schizophrenia. The World Health Organization estimates that schizophrenia affects about 23 million people worldwide—approximately one in every 345.