Why Daily HIV Medication MattersPeople with HIV need to take daily medication to keep the retrovirus suppressed, researchers said. It can be difficult to adhere to such a strict drug schedule, and even a small slip risks a resurgence of HIV, researchers said. How the Once-Weekly Pill WorksThe new pill combines two long-acting antiretroviral medicines, islatravir and lenacapavir. Participants were randomly assigned to take either the new pill or stay on their existing HIV medication. This once-weekly pill could provide greater flexibility for patients while avoiding the need for injectable drugs, researchers said.