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Tibetans carry a Denisovan-like DNA segment around EPAS1 that is associated with lower hemoglobin at high altitude, showing how interbreeding with an extinct human population contributed to life on the plateau
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ScienceBlog.com
Other oxygen-response genes, including EGLN1, also carry selected variants in Tibetan populations.
The study identified the ancestry of a selected DNA segment.
A separate 2014 study led by Choongwon Jeong found that Sherpa and Tibetan populations share selected high-altitude ancestry around both EPAS1 and EGLN1.
Variants near EPAS1 were associated with lower hemoglobin in the Sherpa sample in the same direction previously reported among Tibetans.
The Tibetan EPAS1 haplotype is one of the clearest examples of the last outcome.