Christian McCaffrey hopes to fully fit and ready for the start of the 49ers' 2026 campaign, trying to avoid issues he had in 2024. Injury woes continue to be on Christian McCaffrey's radar as the superstar running back gears up for the San Francisco 49ers' 2026 campaign. “Christian McCaffrey in 2024: Placed on IR with “calf tightness” in Week 1, didn't return until Week 10. What lies ahead for Christian McCaffrey, 49ersArticle Continues BelowChristian McCaffrey will hope for the best news that his latest injury doesn't hold him back. McCaffrey went through 2025 as a dominant player even though San Francisco went throughout multiple injuries across the roster.