Critically, Cartwright's prediction is not an official announcement of the beginning of the end, but, if Cartwright is correct, that would mean The Simpsons will say goodbye at some point in 2028. That would mean The Simpsons would miss Lisa succeeding Donald Trump as President by a matter of mere months. Cartwright was surprisingly forthright when Rosenbaum asked her point-blank about long The Simpsons will end up going. Cartwright gave him a blunt answer of “40,” implying 40 seasons, surprising the host with her honesty. Rosenbaum asked Cartwright.