SHCC is a rare form of hepatocellular carcinoma, whereas IMCC is a primary bile duct cancer that develops within the liver. MRI Features Strengthened Diagnostic AccuracyResearchers assessed clinicopathological characteristics alongside gadolinium ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced MRI findings to identify factors that distinguished SHCC from IMCC. Compared with IMCC, SHCC showed a significantly lower incidence of necrosis in both the training and validation cohorts (training: p= 0.03; validation: p=0.002). Multivariable analysis identified three imaging features as independent diagnostic indicators: non-thin rim enhancement during the arterial phase, an enhancing capsule, and signal loss on opposed-phase T1-weighted imaging. Differentiating scirrhous hepatocellular carcinoma from intrahepatic mass-forming cholangiocarcinoma based on Gd-EOB-DTPA-enhanced MRI and serum biomarkers in an HBV-positive high-risk cohort: a multi-center study.