So, what is the most reliable car brand? Brands like Toyota, Lexus, Subaru, Honda, and Mazda routinely earn high marks, though the exact rankings vary from study to study. What Do Car Shoppers Think? But discussions among car shoppers on Reddit suggest the answer isn't quite that simple. Bottom line: There isn't a single "most reliable" car brand every year, but if you're shopping strictly for dependability, it's hard to go wrong with Toyota or Lexus.