What is the GLP-1 alternative BRP? “BRP appears to suppress appetite through a different brain signaling pathway from GLP-1,” explains Cuilan Li, MD, PhD, a women’s health specialist for JustAnswer. Dr. Li says it’s possible, but making BRP an accessible GLP-1 alternative could take a while. Staying hydrated: We can sometimes confuse thirst with hunger, and Dr. Li says staying hydrated helps avoid this issue. If you find they aren’t for you, talk to your doctor about other methods—including GLP-1 alternatives—to help you reach your goals.