Israeli Clalit data shows higher survival for patients using statins and sildenafilSildenafil, an active ingredient used to treat erectile dysfunction, may slow the development of cancer metastases. While cGMP causes vasodilation in blood vessels, inside cancer cells it binds to a protein responsible for cholesterol transport. Without this component in their membranes, cancer cells cannot effectively detach from the primary tumor to create secondary foci. Synergistic EffectThe study suggests a synergistic effect between sildenafil and statins: one prevents cells from using cholesterol, while the other inhibits its synthesis. However, this research is not a clinical guideline for cancer treatment.