The ‘little blue pill’ may strengthen a newly discovered cholesterol-regulating mechanism that could be harnessed to curb cancer spread. Cholesterol is particularly important for cancer cells seeking to break away from the primary tumor, migrate throughout the body and invade distant organs. Elevated cGMP levels dilate blood vessels, increasing blood flow to the penis – the effect that has made Viagra a successful treatment for erectile dysfunction. As a result, less cholesterol is available for the cell’s needs, and cancer cells, it turns out, are particularly vulnerable to this reduction in cholesterol supply. The combination could not only limit cancer cells’ access to existing cholesterol but also prevent them from producing new cholesterol, potentially enhancing the anti-metastatic effect.