A combination of omega-3 and low-dose acetylsalicylic acid (ASA) produced results comparable to antibiotics in treating severe periodontitis. The control group received placebos of the antibiotics, omega-3, and ASA in capsules identical to those used for the active treatments. The fourth group received a combination of the two strategies simultaneously: antibiotics for two weeks and the omega-3 and ASA protocol for six months. Among those who received omega-3 and ASA, the percentage was virtually the same: 57.7%. “We imagined that the combination of antibiotics and omega-3 would be most effective in controlling periodontitis in these patients.