Orexin Neurons Already Had a Day JobThese cells are not newly discovered, and their established roles are part of why the finding is interesting. Their best-known clinical association is narcolepsy, in which loss of orexin neurons produces the disorder's sleep-wake instability. Recent work had suggested orexin neurons also influence motivated behavior, but their specific role was unclear. Frequently Asked QuestionsWhat are orexin neurons? What should someone with motivational loss do?