The phases ran sequentially: universal decolonization alone, routine care as a control, once-daily enhanced cleaning alone, and decolonization combined with enhanced cleaning. Bedroom contamination fell 84 percent compared with control and 74 percent compared with enhanced cleaning. Enhanced cleaning alone did not reduce carriage or bedroom contamination, and it added no measurable benefit for those outcomes when combined with decolonization. Common areas were the exception: there, where cleaning was performed after activities, decolonization and enhanced cleaning produced similar reductions in contamination, and the combination worked better than either alone. MedicalDaily will report further research and any changes to federal long-term care infection control guidance.