Dust off all those electrical substation jokes surrounding the San Francisco 49ers (honestly, they shouldn't have too much dust on them at this point). 49ers' worst injury-plagued seasons2026 —Training camp blues: Before the regular season even started, the Niners were missing 20 players out of their 90-man camp roster. —Super Bowl hangover: Scores of injuries led to San Francisco using 140-plus gameday injured-reserve designations, worst in the NFL, leading to a 6-11 record following a brutal Super Bowl defeat. 2020 —The worst of the worst: Another Super Bowl hangover, and a historically unprecedented rash of injuries. —The worst of the worst: Another Super Bowl hangover, and a historically unprecedented rash of injuries.