Aug 7: Proteogenomics represents a transformative approach in cancer research that bridges the gap between genomic alterations and their functional consequences at the protein level. Post-translational modifications, particularly phosphorylation, represent a critical layer of regulation that cannot be inferred from genomic data alone. The clinical utility of proteogenomics is increasingly being demonstrated across multiple cancer types. In breast cancer, proteogenomic subtyping has refined our understanding of disease heterogeneity beyond traditional genomic classifications. In colorectal cancer, proteogenomic analyses have revealed distinct molecular subtypes with therapeutic implications.