The Carolina Panthers and Arizona Cardinals kicked off the NFL Preseason slate on Thursday night in Canton, and the Buffalo Bills aren't far behind. Bills head coach Joe Brady leads the offense through drills during day five of Buffalo Bills training camp at St. John Fisher University Tuesday, August 4, 2026 in Pittsford. | USA TODAY Network via Reuters ConnectAugust 15 vs. Carolina Panthers (1 p.m.)The Bills open their three-game preseason slate with a home Saturday matinee against the Carolina Panthers. Oct 26, 2025; Charlotte, North Carolina, USA; Buffalo Bills running back James Cook III (4) scores a touchdown during the second half against the Carolina Panthers at Bank of America Stadium. Nov 30, 2025; Pittsburgh, Pennsylvania, USA; Buffalo Bills running back James Cook III (4) rushes as Pittsburgh Steelers defensive end Yahya Black (94) defends | IMAGN IMAGES via Reuters Connect— Sign up for OnSI’s Free Buffalo Bills Newsletter —