After being acquired at the Major League Baseball trade deadline to address the Padres starting pitching problem, Mize made his debut for the San Diego Padres Wednesday night in Arizona. The Arizona Diamondbacks beat the Padres 10-4. After getting the first out in the 4th, Mize allowed 5 straight Arizona hits and issued a walk before departing the game. The 8 runs allowed raised Mize season earned run average from 2.70 to 3.40. It was Tatis 161st career home run with the Padres, tying him for 3rd most all-time for the Padres franchise.