Exemptions would be allowed for substances already listed by FDA, substances that have received a no-questions letter, or substances covered by an existing regulation. The Wider Regulatory Moment This Sits InThe GRAS proposal is not moving alone, which is context worth having. Taken together, these are among the most significant proposed changes to federal food ingredient policy in many years. FDA's proposed rule on substances generally recognized as safe completed White House regulatory review on July 31. It has not been published, and a proposed rule still requires public comment and a separate final rule before taking effect.