The label change means as few as six maintenance injections per year rather than twelve, and it does so without requiring a concurrent prescription topical. The approved course starts with 500 mg, given as two 250 mg injections, at week 0 and again at week 2. That extension compared maintenance dosing every eight weeks against every four weeks. Ask whether you have reached the point in the course where maintenance dosing applies. The course begins with 500 mg at weeks 0 and 2, then 250 mg every two weeks through at least week 16, before maintenance dosing applies.