Overview GLP-1 medications help make weight loss easier by changing the body's hunger signals, reducing the effort it takes to eat less. GLP-1 medications such as Ozempic, Wegovy, Mounjaro, and Zepbound have changed the treatment of obesity and Type 2 diabetes. Tronieri said GLP-1 medications help make weight loss easier by changing the body’s hunger signals, reducing the effort it takes to eat less. The most common side effects of GLP-1 medications for people with and without diabetes are gastrointestinal, including nausea, vomiting, constipation, and diarrhea, said Tronieri. Jasmyne Cannick, an award-winning journalist, shared her experience using GLP-1 medications for weight loss.