Immune cells arrived at the site of infection or injury, eliminated the threat, and then simply disappeared. However, we don’t often discuss the role of immune cells interacting directly with sensory nerves. So, I would always be cautious when someone claims they have a single pro-resolution therapy that could treat every inflammatory disease. Each flare can bring another wave of inflammatory cells into the skin, joints, kidneys, or other organs. They develop less redness and swelling, fewer immune cells infiltrate the tissue, and they generally report less inflammatory pain than males.