Photo by Jim Harris on Unsplash wine barrel lotWhen it comes to wine regions, Colorado doesn't really come to mind, does it? Colorado Wine Region Ranked Among Best in AmericaThere are wine regions all over the United States and in places you might not have thought would be sustainable for a winery. This wine region has some of the highest-elevation vineyards in North America, making the wine fresh, smooth, aromatic, and most importantly, flavorful. 2 on USA Today 10Best ListThe West Elks Viticultural Area makes the best wine regions list from the wine characteristics above, plus two major annual events in the region. North Fork Uncorked and the West Elks Wine Trail.