But in a recent interview with Andy Cohen, the 55-year-old actor also credited a “gut cleanse with my doctor, who told me to take 90 days to not eat gluten, dairy, alcohol, caffeine, or sugar.” While the main motivation for Damon’s restrictive diet was shredding to reach Greek god tier, gut cleanses have also become popular among wellness enthusiasts seeking primarily to improve their digestive health. What is a gut cleanse meant to do? Does a gut cleanse work? Similarly, there’s no strong evidence that gut cleanse supplements will support this process, and some of them could be harmful.