Recognising that every young person lost to substance use represents a dream interrupted, a family under strain, and a loss to society, the Policy Brief advocates a coordinated, evidence-based and long-term institutional response. The Policy Brief emerged from the two-day workshop, “Drug-Free Society: A Call for Collective Action,” organised by IUST as part of the 100-Day Nasha Mukt Campaign launched under the leadership of the Lieutenant Governor, Manoj Sinha. While representing diverse sectors, participants shared a common understanding that addressing substance use requires collective action and sustained institutional collaboration. Drawing upon these deliberations, the Policy Brief presents a practical framework to strengthen existing efforts by improving institutional coordination and integrating prevention, treatment and rehabilitation within a shared policy vision. The Policy Brief recommends a coordinated institutional framework involving Government departments, educational institutions, healthcare systems, local self-government institutions, law enforcement agencies, civil society organisations and community groups.