If you've ever alternated between Tylenol and Aleve for pain relief, a new over-the-counter option may soon make that easier. The FDA has approved the first nonprescription medication that combines acetaminophen, the active ingredient in Tylenol, with naproxen, the active ingredient in Aleve, into a single tablet. Acetaminophen and naproxen work in different ways, so together they can provide both fast-acting and longer-lasting pain relief. Clinical studies found the combination provided better pain relief than either medication alone. For example, if you're taking this new combination product, you should not also take another Tylenol product unless your healthcare provider tells you to.