> ScienceThree of the most common medicines used have been classified as carcinogenic by the World Health Organization's cancer research arm. The International Agency for Research on Cancer has placed hydrochlorothiazide, voriconazole, and tacrolimus in its Group 1 category. These three drugs appear on the WHO’s list of essential medicines and are prescribed to large numbers of patients worldwide. Does Hydrochlorothiazide Cause Skin Cancer? According to the paper, there is sufficient evidence that long-term use of hydrochlorothiazide raises the risk of squamous cell skin cancer and cancer of the lip.