A cannabis extract rich in neutral cannabinoids significantly reduced ultraviolet B (UVB)-induced oxidative stress and partially restored a key regulator of pigment-producing cells, according to a new laboratory study. Researchers said the findings support further investigation into cannabis extracts as potential ingredients in dermatological products designed to protect skin cells from sunlight-related oxidative stress. Researchers tested an ethanolic Cannabis sativa extract using B16-F10 pigmented melanoma cells, a mouse-derived cell line commonly used to study pigmentation and oxidative stress. Pretreatment with 25 micrograms of cannabis extract per milliliter significantly reduced that increase. Cannabis extract reduced that increase in a dose-dependent manner, reaching statistical significance at 100 micrograms per milliliter.