The European Union’s Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) Regulation is widely regarded as one of the world’s most comprehensive and influential pieces of chemicals legislation. Nearly two decades later, the REACH Regulation continues to evolve in response to emerging scientific evidence and new environmental challenges. None has proved more significant than per- and polyfluoroalkyl substances (PFAS), a vast group of synthetic chemicals whose persistence in the environment has earned them the nickname “forever chemicals”. REACH milestonesThe REACH Regulation has continued to evolve since its introduction as scientific understanding and regulatory priorities have developed. The next chapter for REACHNearly 20 years after entering into force, REACH remains the cornerstone of European chemicals regulation.