The latest public press releases about the production have given more information on who we can expect to see bring the new take to life. What’s Romy and Michele about? Two lifelong friends prepare to get ready for their high school reunion, with one small snag. They’re desperate to impress the crowd of ex-classmates who have appeared to have been catapulted much further ahead in life than they have. To tell everybody that they’re the geniuses behind the modern-day invention of the Post-it note.