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Researchers Map the Six Enzymes Two Poisonous Garden Flowers Use to Build a Medically Interesting Alkaloid
['Elena Vega']
Medical Daily
That leaves a third route: identify the enzymes the plant uses and transfer the genetic instructions into a host organism that grows quickly and safely.
It does not mean beneficial, and in this plant family the same chemistry produces aconitine, a compound notorious for severe cardiac and neurological toxicity.
A Word About the Plants ThemselvesBecause this research names two common garden plants, one practical safety note belongs here.
The six enzymes that Siberian larkspur and garden monkshood use to build a diterpenoid alkaloid called atisinium, including a reductase with little resemblance to previously characterized enzymes.
Identification of the remaining enzymes in the pathway and engineering of a host organism capable of producing the compounds reliably.