And as the disease progresses, agitation can become one of its most troubling symptoms. Dr. Gregory Jicha, the University of Kentucky's director of clinical trials, said agitation is a significant concern in later stages of the disease. "Over 40% of all patients in the later stages of disease will present with agitation," Jicha said. "They showed a dramatic effect with an improvement in agitation scores," Jicha said. The University of Kentucky team took the trial directly to patients across the state.