Coffee may benefit heart and metabolic health beyond caffeine contentCoffee contains numerous bioactive compounds that influence metabolic and cardiovascular health beyond the effects of caffeine. Neither caffeinated nor decaffeinated coffee changed body weight, BMI, or blood pressure during the study, however there was an increase in Sirt-1 levels after caffeinated coffee consumption in Group B. After decaffeinated coffee, sRAGE was associated with glycated hemoglobin, small dense LDL, and Sirt-1, whereas after caffeinated coffee, sRAGE became positively associated with Sirt-1 and glucose and inversely associated with lipoprotein(a). The researchers suggested that decaffeinated and caffeinated coffee may affect different metabolic pathways, with caffeine potentially enhancing energy-sensing pathways and Sirt-1 activation. “Specifically, homocysteine emerges as an upstream determinant of RAGE signaling only in leaner individuals after consuming either caffeinated or decaffeinated coffee.”