Scientists are now exploring whether natural compounds can help the aging immune system work more effectively. At the same time, aging immune cells begin to accumulate damage and lose their ability to respond quickly to infections. Scientists refer to this gradual decline as immunosenescence, which is one reason vaccines sometimes provide less protection in older people. Their antibody levels increased, their antibodies became better at blocking several coronavirus variants, and important markers linked to immune aging decreased. Rather than changing the vaccine itself, researchers hope to improve the body’s ability to respond to vaccination by making aging immune cells healthier.