Scale-up calls forprocess handoff tools for CRO request triggers, expression yields, or purification parameters— "Does this translate?" The question is "where does scientific judgment live, and what happens to that judgement at each handoff?" Scientists need the ability to store the process and the design rationale alongside the molecule. Scientific Judgment Shouldn't Evaporate at the HandoffMost platforms have solved the storage problem, which is about where the data live. The harder problem for complex modalities is that the scientific judgment behind the data was never captured as a first-class object, because it lived in someone else’s head.