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Lean and Obese Patients with Newly Diagnosed Type 2 Diabetes Show High Atherogenic Risk: JAPI Study
['Aashi Verma', 'Written']
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Key Clinical Findings of the Study Include:Significant AIP Elevation: The study noted that the atherogenic index of plasma was significantly higher in obese patients compared to lean ones (0.7 vs. 0.6, p = 0.006), serving as a sensitive indicator for future coronary complications.
Surpassed Cholesterol Cutoffs: Researchers observed that the Total Cholesterol (TC) to High-Density Lipoprotein Cholesterol (HDL-C) ratio reached 6.7 in obese subjects and 5.9 in lean subjects, both surpassing the recommended 3.5 clinical threshold.
Inverse Glycemic Trends: The investigation found that lean patients exhibited significantly worse glycemic control, with a mean Glycated Hemoglobin (HbA1c) of 11.5% compared to 9.42% in the obese cohort.
High Proatherogenic Potential: The Low-Density Lipoprotein Cholesterol (LDL-C) to High-Density Lipoprotein Cholesterol ratio was found to be 4.8 in the obese group and 4.0 in the lean group, both exceeding the sensitive predictor threshold of 2.517.
Atherogenic Indices in Newly Diagnosed Obese and Lean Patients of Type 2 Diabetes Mellitus: A Comparative Study.