Scientists Have Found The Brain Circuit Behind Misophonia's 'Rage Response'

As many as one in five of us have misophonia, a severe reaction to everyday sounds such as chewing or sniffing. Despite it being relatively common, misophonia's origins in the brain are still something of a mystery. This brain region is part of what's known as the salience network, which processes numerous internal and external cues. The study found that brain activity linked to misophonia was distinct from other conditions. Brain Mapp., 2026)What's more, this clustering didn't meaningfully overlap with brain activity linked to anxiety, depression, or traits of autism.