Rare form: Two new studies use antisense oligonucleotides (ASOs) to investigate mechanisms of autism-related conditions. One paper reports that ASOs targeting SCN2A variants reduced seizures and improved language and motor skills in two children with developmental and epileptic encephalopathies. The other study, a preprint, used ASOs to reveal molecular pathways from a truncated ASXL3 gene to broader genomic and translational changes observed in Bainbridge-Ropers syndrome. Studies of rare genetic disorders such as these often rely on data from very few participants, as The Transmitter has previously covered, to develop bespoke treatment strategies. Autism research spotted this week: