(COLUMBUS, Ohio) — The Ohio Narcotics Intelligence Center (ONIC) released two public safety bulletins on Friday (July 31, 2026) alerting Ohioans of dangerous substances showing up in Ohio’s drug supply. Orphines are a sub-group of new synthetic opioids (NSOs) which are being encountered in seized drug samples and suspected overdose incidents across Ohio. A person experiencing a drug overdose involving multiple drugs may still demonstrate symptoms of intoxication even after breathing is restored. Naloxone is safe and should be used in the event of a suspected overdose. Operated as a division of the Ohio Department of Public Safety, ONIC has locations in Columbus, Cleveland, Toledo, and Cincinnati.